What is CBD Oil?
The cannabis plant houses more than 400 cannabinoids and terpenes; however, the two leading cannabinoids are CBD-cannabidiol and THC-Tetrahydrocannabinol.
These chemicals are highly regarded for their health benefits; however, CBD is non-psychoactive, and THC brings euphoria and intoxication.
CBD after extraction from the hemp plant is mixed with a carrier oil such as coconut oil, hemp seed oil, or olive oil. These oils are responsible for the better digestion of CBD oil.
It is worth mentioning that CBD oil manufacturers make three different types of CBD oil: full-spectrum, broad-spectrum, and CBD-isolate, depending on the cannabinoid profile.
The full-spectrum contains all chemicals of hemp, including less than 0.3% THC, while the broad-spectrum contains all cannabinoids except THC. CBD isolate is the purest CBD form.
Many CBD users vouch for full-spectrum and broad-spectrum because they can enhance the overall CBD effects due to the synergy of the chemicals. However, those reluctant to use THC prefer CBD-isolate or broad-spectrum CBD oil only.
CBD oil and Seizures
Cannabis has been long hauled to alleviate symptoms of epilepsy for centuries. It was only recently made lawful in the United States to use cannabis products for therapeutic purposes. In 2018, the FDA authorized Epidiolex, CBD oil for epilepsy, to address specific epileptic conditions.
It is worth mentioning that about a third of individuals with epileptic seizures develop drug-resistant epilepsy, which says standard medications do not control their episodes. The idea that medicinal cannabis could assist persons with drug-resistant epileptic seizures referred to as refractory epilepsy, decreases and even eliminates attacks.
How does it work?
It is unclear how CBD can help with certain types of epilepsy as the CBD research in medicine is still in its infancy. However, it is proven to have a broad range of biological reactions on cerebral neurons, potentially influencing seizures and convulsions.
It is worth noting that seizures are triggered by unpredictable electrical impulses in brain cells, increasing and resulting in uncontrollable bodily motions or changes in perception. The majority of anti-seizure medications function by reducing exuberant neuronal neural activity.
Now coming to how CBD oil works for reducing epilepsy seizures, your body has an innate network of neurotransmitters and receptors that regulate different bodily functions.
In other words, they regulate the functions such as metabolism, sleep and wake cycle, pain, and inflammation that get out of the line. This cell signaling system is known as the Endocannabinoid System. Comprehensive analysis of CBD oil for pain, inflammation, sleep to play an effective help.
According to a mouse study, CBD’s antiepileptic benefits may be due to its lowering neuronal stimulation by working on two receptor classes termed GPR55 and TRPV1 receptors.
How does CBD oil benefit seizures and epilepsy–According to Research?
The potential of CBD oil to cure absence seizures or epilepsy is still under investigation. As mentioned earlier, Epidolex, an FDA-approved medical prescription for epilepsy, can treat specific and rare epilepsy types like Lennox-Gastaut and Dravet syndromes.
Besides, treating these syndromes can also help with the tuberous sclerosis complex that causes epileptic seizures due to genetic problems.
Lennox-gastaut syndrome is an uncommon type of epilepsy that affects approximately 2-5% of early years epilepsy cases.
Regarding the LGS, scientists conducted a research where they evaluated the efficacy of the Epidiolex on LGS sufferers. During this 14 day trial, the scientist found some promising results.
In the first phase of the investigation, the researchers administered 20 mg epidolex per kg to weight each day to the LGS sufferers.
In contrast to the controlled group, almost half of the sufferers taking epidiolex had 44% fewer episodes. On the other hand, the placebo group participants experienced a 22% decrease in seizures.
The second trial examined the effectiveness of regular Epidolex dosages of 10 mg per kg of the body weight and 20 mg per kg of the bodyweight against a placebo.
Compared to the control group, all Epidolex groups experienced a substantial decrease in symptoms.
50% of subjects that consumed 20 mg per kg bodyweight of Epidiolex daily had 42% fewer episodes.
Half of the individuals that received 10 mg per kg of body weight per day had a 37% reduction in attacks. Half of the patients had 17 percent reduced epilepsy compared to the placebo. Considering the research results, CBD oil for autism and epilepsy works wonders.
Dravet syndrome is another epilepsy type that is not that common among sufferers. Dravet syndrome is the type of seizure that disturbs the ability of the body to respond to medication appropriately.
In another medical research, some researchers studied the efficacy of 20mg per kg of body weight in subjects aged two years to 18 years. Compared to placebo groups, those administered with epidiolex substantially decreased the episodes by 39%, while the placebo group dropped by only 17%.
Since Epidiolex has CBD as an active ingredient considering the search results, CBD hemp oil works for seizures.
Tuberous Sclerosis complex
The Tuberous Sclerosis Complex is a genetic disease that can only happen to 1 in 6,000 individuals. The condition triggers non-cancerous tumors to increase in different body parts; however, the tumors growing in the brain can cause epileptic seizures.
While CBD oil works against grand mal seizures, it also does it for tuberous sclerosis complex as a clinical trial. Researchers assessed the effectiveness of the 25 mg and 50 mg of Epidiolex per day on 148 subjects suffering tuberous sclerosis complex. The average improvement in seizures was 48% and 24% for Epidiolex and control groups, respectively.
Other Causes of Seizures
More investigation is necessary to see if CBD can be used to treat different types of seizures, although preliminary research has yielded encouraging results for CBD oil and seizures.
Besides minimizing epilepsy episodes, CBD can also boost the working of prescribed epilepsy medications. According to research, CBD oil affects seizures by maximizing the effects of clobazam, the medicine that treats epilepsy. Be]sides, there are also research findings that enhanced the efficacy of anti-seizure medications.
According to research in 2018, CBD oil worked for different epilepsy types. The researcher examined the 55 subjects suffering from four other epilepsy seizures that are:
- CDKL5 deficiency is a genetic disease that causes epilepsy ts and developmental delays
- Aicardi syndrome is a rare congenital disorder
- Doose syndrome or Myoclonic atonic epilepsy (MAE) affects children aged 2 to 6 years
- Duplication of the 15th chromosome (Dup15q)
The subjects experienced a median of 59.4 episodes monthly at the start of the study. After three months, the monthly average had dropped to 22.5%. And over the study’s 48 weeks, the enhanced percentage remained unchanged.
While CDKL5, MAE, and DUP15q cause epilepsy attacks, Aicardi syndrome causes cognitive disabilities and developmental delays. So besides curing the seizures, CBD oil works for non-epileptic seizures.
Does CBD Oil for Child seizures Work–What does research Say?
It is worth noting that Epidiolex is licensed to use for even children of 2 years and above. In simple words, children who have epilepsy that does not benefit from prescribed medication can get health rewards from CBD.
As per a study CBD, whether separately or as a combination of Cannabidiol essential oils, reduces epilepsy prevalence in adolescents with treatment-resistant epilepsy.
Although data supporting CBD can lessen seizure frequency with drug-resistant epilepsy, similar findings do not apply to other hemp chemicals in the plant, according to independent research published in Epilepsia.
According to researchers, CBD is the only approved chemical of cannabis having these qualities.
CBD may not be beneficial for all youngsters in terms of long-term performance. According to a study published in CNS Drugs, CBD was helpful in roughly 27% of adolescents with treatment-resistant convulsions over four years. Nevertheless, side effects were reported by 81 percent of individuals, with 23 percent reporting severe side effects.
What is the dosage of CBD oil for seizures?
Epidiolex is available as an edible mixture, and the suggested dosage is determined by body weight.
CBD oil’s epilepsy dosage is usually initiated at 2.5 mg per kilogram of body weight two times a day and gradually raised weekly. The dose can be elevated to a maximum of 20mg per day if necessary; however, the greater quantity has been linked to more side effects.
Anti-seizure drugs must be administered as recommended, with no missed or combined dosages. Moreover, CBD oil dosage for epilepsy must be continued or withdrawn progressively, just like other antiepileptic drugs, because abrupt modifications can worsen seizure frequency.
Can CBD Disturb the other Prescribed medications taken for seizures?
CBD may interfere with the effectiveness of other epilepsy treatments; that is, it potentially renders the drug better or least helpful in some circumstances. According to a study, the CBD is usually correlated to interact with the following treatments:
- Valproic acid
Remember that you must not use CBD oil as a substitute for standard seizures drugs except your therapist tells you so. Moreover, the doctor can assist you in carefully adjusting the dosages of your prescription and CBD.
Are there any harmful side effects of using CBD for seizures?
CBD is generally a noble cannabinoid with no intoxicating and severe side effects. However, there are some mild side effects of the compound that first-time users might encounter:
- Stomach discomfort
- Appetite change
Although CBD is safe for use, it entails the risk of liver toxicity if taken with some specific drugs. Moreover, several black sheep are selling mislabeled CBD products commercially.
For that, it is always a good practice to check third-party lab results and the constituents of the CBD oil. The best CBD oil for epilepsy comes with less than 0.3% THC and no toxic chemicals.
According to a study, although CBD oil is best for seizures, it increases epilepsy episodes in some individuals. For that, we always recommend consulting your medical expert first and then buying CBD oil for seizures.
What are CBD products recommended for seizures?
There is a huge debate around the efficacy of one CBD product over the other. However, there is a phenomenon stating that therapeutic benefits of CBD can be upshot as of the synergetic effect of all the chemicals in unison. This phenomenon is known as the entourage effect.
So for those who want to cherish the entourage effect, the Full-spectrum CBD oil is a good pick.
Moreover, in a 2018 assessment of studies, scientists concluded that CBD-rich hemp supplements appear to be more beneficial than CBD at decreasing epilepsy occurrence, although further trials are essential.
In a recent study in 2020, the researchers discovered that individuals who used a commercially available CBD product experienced a 70% rise in episodes. Still, those who took prescribed CBD showed a 39% drop.
This phenomenon may be because many commercialized CBD products contain larger quantities of High ingredient THC, which can cause more frequency in epilepsy episodes.
Even though this trial was limited, with just 31 subjects, it emphasizes the necessity of utilizing a good and correctly labeled CBD product.
While Epidiolex is subjected to strict production processes and has a constant dose because it is FDA authorized, the commercial CBD products go around the law and come with high amounts of THC or other harmful chemicals. For that, we always recommend going with a reputable brand CBD products that come with all the authentication proof of the products.
Conclusion: CBD Oil for Seizures & Epilepsy
CBD’s potential to prevent epilepsy and seizures is still being researched. CBD is now licensed to treat seizures induced by two uncommon epilepsy types and tuberous sclerosis complex.
In some preliminary research, CBD has been demonstrated to be a therapeutic option for various other attacks. We do not recommend CBD as a substitute for your prescribed medicines.
It’s essential to see your therapist before using CBD products if you’re experiencing epilepsy.